A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia
نویسندگان
چکیده
منابع مشابه
Low-dose metronomic daily cyclophosphamide and weekly tirapazamine: a well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia.
The recent clinical successes of antiangiogenic drug-based therapies have also served to highlight the problem of acquired resistance because, similar to other types of cancer therapy, tumors that initially respond eventually stop doing so. Consequently, strategies designed to delay resistance or treat resistant subpopulations when they arise have assumed considerable importance. This requires ...
متن کاملBiopolymer based nanosystem for doxorubicin targeted delivery.
This study describes formation of an actively and passively targeted, water-soluble drug delivery system (DDS) which contains doxorubicin (DOX). The system comprises two biocompatible and biodegradable polymers: poly-γ-glutamic acid (PGA) and chitosan (CH). Self-assembly of these biopolymers in aqueous medium results stable nanoparticles (NPs) with a hydrodynamic size of 80-150 nm and slightly ...
متن کاملProjection onto a Polyhedron That Exploits
An algorithm is developed for projecting a point onto a polyhedron. The algorithm solves a dual version of the projection problem and then uses the relationship between the primal and dual to recover the projection. The techniques in the paper exploit sparsity. SpaRSA (Sparse Reconstruction by Separable Approximation) is used to approximately identify active constraints in the polyhedron, and t...
متن کاملProjection onto a Polyhedron that Exploits Sparsity
An algorithm is developed for projecting a point onto a polyhedron. The algorithm solves a dual version of the projection problem and then uses the relationship between the primal and dual to recover the projection. The techniques in the paper exploit sparsity. Sparse reconstruction by separable approximation (SpaRSA) is used to approximately identify active constraints in the polyhedron, and t...
متن کاملBioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N-isopropyl acr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Science
سال: 2018
ISSN: 2198-3844
DOI: 10.1002/advs.201800034